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Growth factors are powerful biological agents that signal cells to come to a site within the body that needs help healing. They’re key elements of amniotic membrane that, together with specialized cytokines and enzyme inhibitors, are known to help enhance healing—and now can be used to help your own cells regenerate damaged tissue.

What is amniotic membrane?

The amniotic membrane, or amniotic sac, is a portion of the placenta that contains high concentrations of hundreds of growth factors. This portion of the placenta helps the placenta and baby grow. After childbirth, this region of the placenta is harvested, preserved and purified following delivery by mothers who have been screened and donated the tissue.

What is an allograft?

An allograft means that the tissue you’re treated with comes from another human being. However, this tissue is non-immunogenic, meaning there is no risk of rejecting the tissue. These products are rigorously screened and tested for all communicable diseases before going through the purification process that involves terminal sterilization.

Regenerative Medicine. Reimagined.

We use regenerative best practices you won’t find at every medical practice, including amniotic allograft therapy with:

  • 300+ regulatory proteins
  • Terminally sterilized for enhanced patient safety
  • RMAT status from the FDA as a bioactive tissue matrix

Get started with a FREE 15-minute consultation.

Book Now

The AIM Difference

Regenerative Medicine. Reimagined.

We use regenerative best practices you won’t find at every medical practice, including amniotic allograft therapy with:

  • 300+ regulatory proteins
  • Terminally sterilized for enhanced patient safety
  • RMAT status from the FDA as a bioactive tissue matrix

Get started with a FREE 15-minute consultation.

Book Now

How do these products work?

These amniotic membrane products have a biological process that’s similar in theory to PRP injections. However, the growth factors appear in a higher concentration than in PRP, which varies from patient to patient in the amount of growth factors. With amniotic membrane products, tests indicate the quantity of growth factors in each injection. When these purified growth factors are injected into an injured area, they:

  • Modulate inflammation
  • Decrease scar tissue formation and
  • Enhance healing by recruiting stem cells to the site of injury*

*Studies have demonstrated the ability of amniotic membrane allografts to recruit stem cells through chemical signaling.

Amniotic membrane allografts (AmnioFix)

The amniotic membrane allograft used at AIM, called AmnioFix®, won regenerative medicine advanced therapy (RMAT) status from the FDA for its effectiveness in fighting osteoarthritis, specifically in the knee—but it can be used for any joint or spine condition.

AmnioFix is a bioactive tissue matrix composed of human amnion and chorion membrane for homologous use to modulate inflammation, reduce scar tissue formation and enhance healing in soft tissue applications such as full and partial tears of ligaments and tendons. The AmnioFix biologic by MiMedx has over 226 different growth factors, specialized cytokines and enzyme inhibitors, including those that help enhance soft tissue healing. Since 2006, there have been over 400,000 allografts with zero FDA reportable adverse reactions, according to MiMedx.

Is it better than PRP?

Maybe. PRP is subject to several limitations. There is a significant amount of variability in growth factor profiles from donor to donor, which translates to a lack of consistency in clinical outcomes and therapeutic potential [9]. Additionally, the concentrations of certain factors such as EGF, TGF- β, PDGF-AB, PDGF-BB and IGF-1 have been found to decrease as patient age increases (negatively correlated with patient age) [9,15]. Furthermore, sex differences have been reported in the literature, which adds an additional variable to consider when harvesting PRP from older patients.

When to use

Consider AmnioFix as an option if conservative treatments such as anti-inflammatories, physical therapy, and bracing have not provided symptomatic relief, or if you are searching for a non-steroidal option or have reached the limit of steroid injections.

Amniotic allograft therapy may be useful in treating pain associated with the following:

  • Knee osteoarthritis
  • Rotator cuff tendonitis
  • Degenerative arthritis
  • Achilles tendonitis
  • Other related conditions

Most insurances do not cover regenerative treatments. For medical financing options, learn more here or please contact us.

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