The Evolution of Prolozone Therapy™ for Joint and Back Pain Treatment

The Science of Prolotherapy & Its Role in Prolozone Therapy

Prolotherapy involves injecting a small amount of an irritant solution into the damaged area to promote the growth of healthy cells and tissues. The most commonly used irritant solution is dextrose, which acts by dehydrating cells at the injection site, causing mild, localized tissue trauma, and attracting immune cells and growth factors that can differentiate into the notoriously hard-to-repair ligaments, tendons, and cartilage of the joints.

For this reason, prolotherapy injection has shown particularly strong success in treating knee osteoarthritis—both in the short term and the long term: In this 52-week randomized controlled study, patients showed significant functional improvements throughout treatment and at a 2.5-year follow-up.

Because dextrose injections work by inducing controlled swelling in order to trigger the body’s healing response, prolotherapy on its own can exacerbate pain surrounding treatment. This is one of the reasons prolotherapy is usually combined with other therapies—and what makes Prolozone Therapy such a well-rounded treatment:

Prolozone Therapy combines dextrose with local anesthetics, which alleviate the patient’s pain, and ozone, which helps to further control the swelling without diminishing the body’s healing response.

The Science of Ozone therapy & Its Role in Prolozone Therapy

Ozone injections work by introducing ozone, a highly active form of oxygen, into the targeted area of treatment. When ozone is injected, it initiates a cascade of biological reactions in the body.

Ozone stimulates the release of growth factors which help promote the growth of new blood vessels and stimulate the production of collagen, a crucial component for tissue strength and elasticity.

Additionally, ozone injections have been shown to possess potent anti-inflammatory properties, which can help to alleviate pain, as well as support the healing process. When it comes to Prolozone Therapy, this anti-inflammatory effect helps to control the temporary dextrose-induced swelling, without inhibiting the body’s regenerative response to it.

Moreover, ozone injections can improve oxygen utilization and enhance cellular metabolism, the conversion of nutrients into energy that fuels tissue repair.

These qualities make ozone a powerful integration into treatments for treating back pain. In this double-blinded controlled study, significant improvements in both pain and function were reported by 65 patients who received ozone therapy injections to treat their low back and leg pain caused by a herniated lumbar disc.

Another important element of ozone in Prolozone Therapy is its administration as a gas: unlike liquid injections that tend to pool in the injected area, this gaseous component expands and disseminates beyond the injury—making Prolozone Therapy a particularly beneficial treatment for pain in joints that are hard-to-reach, like the knee.

The Science of Neural Therapy and Its Role in Prolozone Therapy

Neural therapy involves the injection of local anesthetics, such as procaine, to instate temporary neural blockage and restore the body’s natural regulatory mechanisms, promoting healing and pain relief.

In the context of Prolozone Therapy, the integration of local anesthetics not only provides patients with a more comfortable injection experience, but it improves the body’s active response to the injection as a whole.